Early symptoms of Parkinson's disease may include: fatigue, muscle aches, clumsiness when performing simple movements (socks, shoes, keys ...), writing disorders ( smaller letters), constipation, depression, one-legged drag or reduced one-handed activity when exercising, desquamation of the skin on the face and pillow. Sometimes the early symptom is tremor when resting intermittently and discreetly.
When typically Parkinson's disease manifests by three basic symptoms are:
Trembling clearly in the extremities, lips, tongue. Tremor is often localized on one side of the body for many years, tremor may temporarily stop when exercising, but then recur, when the sleep stops tremor, tremor is increased, however, there are cases when there is no tremor. .
Stiffness: is one of the most important symptoms, stiff limbs in all muscle groups, difficulty walking, palpation of solid and firm muscles.
Reduce movement: loss of natural movements of facial expressions, limbs, especially when moving. Losing expression, expression like a masked person, less blinking.
Other symptoms: often painful pain, restless sitting, heat, hyperemia, edema, cyanosis, erectile dysfunction, orthostatic hypotension, anxiety depression (about 35 to 40%) ), a few may have hallucinations, paranoia, intellect, are still good, may experience severe dementia ...
In Parkinson's disease, there is no specific test for Parkinson's disease. However, tests help diagnose the cause of parkinson's syndrome.
Staging stages of Parkinson's disease:
Stage 1: There are signs on one side of the body, the patient remains autonomous in activities.
Phase 2: there are signs on the sides but no imbalance.
Stage 3: there are symptoms on both sides of the body that are out of balance but the patient is still able to control his / her activities despite the limitations.
Stage 4: severely impaired but still able to walk, requiring partial support.
Stage 5: the patient must be in a wheelchair or lying in bed, unable to control himself.
Treatment of Parkinson's disease
- The group of drugs for treating Parkinson's disease
There are many groups of drugs that treat Parkinson's as choline inhibitors (e.g., Artan, Trihex ...) group of drugs that directly stimulate dopamine receptors (Sifrol, Trivastal), Dopamine replacement drugs (levo dopa) are dopamine supplements are timely and properly pathogenetic (commonly used drugs are Madopar, Syndopar, Sinemet ..) and dopamine destruction inhibitors (this group is currently rarely available in Vietnam market). If using the levo dopa group should not be combined with vitamin B6.
How to use: start with a low dose, gradually increase to the effective dose and maintain the dose. If you want to replace another medicine, you must replace it gradually, without stopping suddenly.
Unwanted effects: depending on the drug group that has undesirable effects, but the common symptoms are: dry eyes, dry mouth, drowsiness, tachycardia, allergies, postural hypotension, disorders heart rate, stomach ache, nausea, indigestion, constipation ... high doses can cause confusion, hallucinations, agitation.
In addition to the above groups, it is possible to use additional groups of neuroprotective drugs and drugs, this group is not specific to Parkinson's disease but also works by the mechanism of anti-radicals and neural nutrition.
- Other treatments
In the treatment of Parkinson's disease, the first option is drug therapy, other methods are only used when medical treatment is less effective. Including the following methods: Surgery, deep brain stimulation, radiation surgery ... Rehabilitation treatment, traditional medicine: limited effect, no published studies.
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